SR-144528 | B2615

SR-144528 is a cannabinoid (CB) receptor 2 inverse agonist (Ki values ranging from 0.3 to 5.6 nM). Displays >700-fold selectivity for CB2 over CB1 receptors. Blocks the effects of CP-55,940 on forskolin-sensitive adenylyl cyclase activity and MAPK in CHO cells expressing CB2 receptors. Also blocks CP 55,940-induced B-cell activation.

SR-144528 is a cannabinoid (CB) receptor 2 inverse agonist (Ki values ranging from 0.3 to 5.6 nM). Displays >700-fold selectivity for CB2 over CB1 receptors. Blocks the effects of CP-55,940 on forskolin-sensitive adenylyl cyclase activity and MAPK in CHO cells expressing CB2 receptors. Also blocks CP 55,940-induced B-cell activation.

B2615 | SR-144528 DataSheet

Alternate Name/Synonyms: SR144528, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide

Appearance: White solid

Formulation:

CAS Number: 192703-06-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₄ClN₃O

Molecular Weight: 476.05

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >40 mg/ml in DMSO, >40 mg/ml in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A cannabinoid (CB) receptor 2 inverse agonist

MDL Number:

PubChem CID: 3081355

SMILES: CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)NC3C(C4CCC3(C4)C)(C)C)C5=CC(=C(C=C5)Cl)C

InChi: InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1

InChi Key: SUGVYNSRNKFXQM-XRHWURSXSA-N