SR-4370 | B3324

SR-4370 is a potent and selective inhibitor of histone deacetylase 3 (HDAC3; IC50 = 6 nM). It displays selectivity for HDAC3 over HDAC1, -2, -6, and -8 (IC50s = 0.13, 0.58, 3.7, and 2.3 µM, respectively). SR-4370 suppresses AR signaling and in vivo prostate tumor growth.

SR-4370 is a potent and selective inhibitor of histone deacetylase 3 (HDAC3; IC50 = 6 nM). It displays selectivity for HDAC3 over HDAC1, -2, -6, and -8 (IC50s = 0.13, 0.58, 3.7, and 2.3 µM, respectively). SR-4370 suppresses AR signaling and in vivo prostate tumor growth.

B3324 | SR-4370 DataSheet

Alternate Name/Synonyms: 2',3'-difluoro-[1,1'-biphenyl]-4-carboxylic acid, 2-butylhydrazide SR4370

Appearance: Crystalline solid

Formulation:

CAS Number: 1816294-67-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₈F₂N₂O

Molecular Weight: 304.33

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent histone deacetylase 3 (HDAC3) inhibitor

MDL Number:

PubChem CID: 118418385

SMILES: FC1=CC=CC(C2=CC=C(C(NNCCCC)=O)C=C2)=C1F

InChi: InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)

InChi Key: OSQKWTZHYXRTBG-UHFFFAOYSA-N