Description
SR-717 is a non-nucleotide STING (stimulator of interferon (IFN) genes) agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Displays antitumor activity.
SR-717 is a non-nucleotide STING (stimulator of interferon (IFN) genes) agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Displays antitumor activity.
B3216 | SR-717 Lithium DataSheet
Alternate Name/Synonyms: SR717,lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
Appearance: Crystalline solid
Formulation:
CAS Number: 2375421-09-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₈F₂LiN₅O₃
Molecular Weight: 351.19
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >10 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A non-nucleotide STING agonist
MDL Number:
PubChem CID: 139434658
SMILES: [Li+].C1=CC(=NN=C1C(=O)NC2=CC(=C(C=C2C(=O)[O-])F)F)N3C=CN=C3
InChi: InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1
InChi Key: ODSAJRWPLSVEHJ-UHFFFAOYSA-M
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |