Description
SR1664 blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5 with an IC₅₀ value of 80 nM (Ki = 28.7 nM) without displaying agonist activity at the PPARγ receptor. It demonstrates potent, dose-dependent anti-diabetic effects in obese mice without inducing fluid retention and weight gain or inhibiting bone formation.
SR1664 blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5 with an IC₅₀ value of 80 nM (Ki = 28.7 nM) without displaying agonist activity at the PPARγ receptor. It demonstrates potent, dose-dependent anti-diabetic effects in obese mice without inducing fluid retention and weight gain or inhibiting bone formation.
Alternate Name/Synonyms: 4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid
Appearance: Yellow solid
Formulation: N/A
CAS Number: 1338259-05-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₃H₂₉N₃O₅
Molecular Weight: 547.6
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: Blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5
MDL Number: N/A
PubChem CID: 50919249
SMILES: CC(C1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC3=C(C=C2)N(C=C3)CC4=CC=C(C=C4)C5=CC=CC=C5C(=O)O
InChi: InChI=1S/C31H25N3O5/c1-20(22-10-13-26(14-11-22)34(38)39)32-30(35)25-12-15-29-24(18-25)16-17-33(29)19-21-6-8-23(9-7-21)27-4-2-3-5-28(27)31(36)37/h2-18,20H,19H2,1H3,(H,32,35)(H,36,37)/t20-/m0/s1
InChi Key: JIHCIAJCNWUMKM-FQEVSTJZSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |