SR1664 | 9432

SR1664 blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5 with an IC₅₀ value of 80 nM (Ki = 28.7 nM) without displaying agonist activity at the PPARγ receptor. It demonstrates potent, dose-dependent anti-diabetic effects in obese mice without inducing fluid retention and weight gain or inhibiting bone formation.

SR1664 blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5 with an IC₅₀ value of 80 nM (Ki = 28.7 nM) without displaying agonist activity at the PPARγ receptor. It demonstrates potent, dose-dependent anti-diabetic effects in obese mice without inducing fluid retention and weight gain or inhibiting bone formation.

9432 | SR1664 DataSheet

Alternate Name/Synonyms: 4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1338259-05-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₂₉N₃O₅

Molecular Weight: 547.6

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Blocks phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) by cyclin-dependent kinase 5

MDL Number: N/A

PubChem CID: 50919249

SMILES: CC(C1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC3=C(C=C2)N(C=C3)CC4=CC=C(C=C4)C5=CC=CC=C5C(=O)O

InChi: InChI=1S/C31H25N3O5/c1-20(22-10-13-26(14-11-22)34(38)39)32-30(35)25-12-15-29-24(18-25)16-17-33(29)19-21-6-8-23(9-7-21)27-4-2-3-5-28(27)31(36)37/h2-18,20H,19H2,1H3,(H,32,35)(H,36,37)/t20-/m0/s1

InChi Key: JIHCIAJCNWUMKM-FQEVSTJZSA-N