Description
SR7826 is a potent and selective LIMK inhibitor with IC₅₀ values 43, 5536 and 6565 nM for LIMK1, ROCK1 and ROCK2 respectively. It has shown to inhibit cofilin phosphorylation in A7r5 cells. In vitro data shows to suppress the migration and invasion of PC-3 cells.
SR7826 is a potent and selective LIMK inhibitor with IC₅₀ values 43, 5536 and 6565 nM for LIMK1, ROCK1 and ROCK2 respectively. It has shown to inhibit cofilin phosphorylation in A7r5 cells. In vitro data shows to suppress the migration and invasion of PC-3 cells.
Alternate Name/Synonyms: N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea
Appearance: Pale Yellow Solid
Formulation: N/A
CAS Number: 1219728-20-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₁N₅O₂
Molecular Weight: 387.43
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (> 35 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: SR7826 is potent and selective LIMK inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(NC1=CC=C(C2=C3C(NC=C3C)=NC=N2)C=C1)N(CCO)C4=CC=CC=C4
InChi: InChI=1S/C22H21N5O2/c1-15-13-23-21-19(15)20(24-14-25-21)16-7-9-17(10-8-16)26-22(29)27(11-12-28)18-5-3-2-4-6-18/h2-10,13-14,28H,11-12H2,1H3,(H,26,29)(H,23,24,25)
InChi Key: WQAGVQVBDHOHRD-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |