SR7826 | B1096

SR7826 is a potent and selective LIMK inhibitor with IC₅₀ values 43, 5536 and 6565 nM for LIMK1, ROCK1 and ROCK2 respectively. It has shown to inhibit cofilin phosphorylation in A7r5 cells. In vitro data shows to suppress the migration and invasion of PC-3 cells.

SR7826 is a potent and selective LIMK inhibitor with IC₅₀ values 43, 5536 and 6565 nM for LIMK1, ROCK1 and ROCK2 respectively. It has shown to inhibit cofilin phosphorylation in A7r5 cells. In vitro data shows to suppress the migration and invasion of PC-3 cells.

B1096 | SR7826 DataSheet

Alternate Name/Synonyms: N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea

Appearance: Pale Yellow Solid

Formulation: N/A

CAS Number: 1219728-20-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₁N₅O₂

Molecular Weight: 387.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: SR7826 is potent and selective LIMK inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(NC1=CC=C(C2=C3C(NC=C3C)=NC=N2)C=C1)N(CCO)C4=CC=CC=C4

InChi: InChI=1S/C22H21N5O2/c1-15-13-23-21-19(15)20(24-14-25-21)16-7-9-17(10-8-16)26-22(29)27(11-12-28)18-5-3-2-4-6-18/h2-10,13-14,28H,11-12H2,1H3,(H,26,29)(H,23,24,25)

InChi Key: WQAGVQVBDHOHRD-UHFFFAOYSA-N