SR9009 | B1210

SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity during dark phase through activation of REV-ERB, altering the expression pattern of core clock genes in the hypothalamai of mice. In in vivo experiments SR9009 has shown to decrease body fat and improved dyslipidemia and hyperglycemia.

SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity during dark phase through activation of REV-ERB, altering the expression pattern of core clock genes in the hypothalamai of mice. In in vivo experiments SR9009 has shown to decrease body fat and improved dyslipidemia and hyperglycemia.

B1210 | SR9009 DataSheet

Alternate Name/Synonyms: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate

Appearance: Off White solid

Formulation: N/A

CAS Number: 1379686-30-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄ClN₃O₄S

Molecular Weight: 437.94

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A REV-ERB agonist

MDL Number:

PubChem CID: 57394020

SMILES: CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]

InChi: InChI=1S/C20H24ClN3O4S/c1-2-28-20(25)23-10-9-16(13-23)12-22(11-15-3-5-17(21)6-4-15)14-18-7-8-19(29-18)24(26)27/h3-8,16H,2,9-14H2,1H3

InChi Key: MMJJNHOIVCGAAP-UHFFFAOYSA-N