Description
SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity during dark phase through activation of REV-ERB, altering the expression pattern of core clock genes in the hypothalamai of mice. In in vivo experiments SR9009 has shown to decrease body fat and improved dyslipidemia and hyperglycemia.
SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity during dark phase through activation of REV-ERB, altering the expression pattern of core clock genes in the hypothalamai of mice. In in vivo experiments SR9009 has shown to decrease body fat and improved dyslipidemia and hyperglycemia.
Alternate Name/Synonyms: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Appearance: Off White solid
Formulation: N/A
CAS Number: 1379686-30-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₄ClN₃O₄S
Molecular Weight: 437.94
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO(>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A REV-ERB agonist
MDL Number:
PubChem CID: 57394020
SMILES: CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]
InChi: InChI=1S/C20H24ClN3O4S/c1-2-28-20(25)23-10-9-16(13-23)12-22(11-15-3-5-17(21)6-4-15)14-18-7-8-19(29-18)24(26)27/h3-8,16H,2,9-14H2,1H3
InChi Key: MMJJNHOIVCGAAP-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |