Stat5 Inhibitor | 9484

STAT5 Inhibitor suppresses STAT5 by targeting its SH2 domain (IC₅₀ = 47 µM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound displays reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ > 500 µM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts. Cell-permeable.

STAT5 Inhibitor suppresses STAT5 by targeting its SH2 domain (IC₅₀ = 47 µM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound displays reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ > 500 µM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.

9484 | Stat5 Inhibitor DataSheet

Alternate Name/Synonyms: (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

Appearance: White solid

Formulation: N/A

CAS Number: 285986-31-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₆H₁₁N₃O₃

Molecular Weight: 293.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Stat5 inhibitor

MDL Number: MFCD00124694

PubChem CID: 2726045

SMILES: C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=O)C3=CN=CC=C3

InChi: InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)

InChi Key: DAVIKTBRCQWOGT-UHFFFAOYSA-N