StemRegenin 1, Free base | 2642

A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.

StemRegenin 1 (SR1) is a cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.

2642 | StemRegenin 1, Free base DataSheet

Alternate Name/Synonyms: 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol; SR1

Appearance: White solid

Formulation: N/A

CAS Number: 1227633-49-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₃N₅OS

Molecular Weight: 429.54

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A promoter of self-renewal of hematopoietic stem cells (HSCs)

MDL Number: N/A

PubChem CID: 46199207

SMILES: CC(C)N1C=NC2=C1N=C(N=C2NCCC3=CC=C(C=C3)O)C4=CSC5=CC=CC=C54

InChi: InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)

InChi Key: BGFHMYJZJZLMHW-UHFFFAOYSA-N