STF-083010 | B2528

STF-083010 is a potent Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. It blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro.

STF-083010 is a potent Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. It blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro.

B2528 | STF-083010 DataSheet

Alternate Name/Synonyms: STF083010; N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

Appearance: Crystalline solid

Formulation:

CAS Number: 307543-71-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₁NO₃S₂

Molecular Weight: 317.38

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An Ire1 inhibitor

MDL Number:

PubChem CID: 135398515

SMILES: C1=CC=C2C(=C1)C=CC(=C2C=NS(=O)(=O)C3=CC=CS3)O

InChi: InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+

InChi Key: TVIVJHZHPKNDAQ-MHWRWJLKSA-N