STF-31 | 9585

STF-31 is a potent glucose transporter 1 (GLUT1) inhibitor (IC₅₀ = ~ 1 µM). It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress GLUT1. Recently, STF-31 has been shown to inhibit the enzyme activity of nicotinamide phosphoribosyltransferase (NAMPT) in biochemical assay in vitro.

STF-31 is a potent glucose transporter 1 (GLUT1) inhibitor (IC₅₀ = ~ 1 µM). It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress GLUT1. Recently, STF-31 has been shown to inhibit the enzyme activity of nicotinamide phosphoribosyltransferase (NAMPT) in biochemical assay in vitro.

9585 | STF-31 DataSheet

Alternate Name/Synonyms: 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 724741-75-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅N₃O₃S

Molecular Weight: 423.53

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent glucose transporter 1 (GLUT1) inhibitor

MDL Number: MFCD04153828

PubChem CID: 984333

SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3

InChi: InChI=1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27)

InChi Key: NGQPRVWTFNBUHA-UHFFFAOYSA-N