STIMA-1 | 9437

STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.

STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.

9437 | STIMA-1 DataSheet

Alternate Name/Synonyms: 2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis

Appearance: Off-white solid

Formulation: N/A

CAS Number: 91634-12-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₈N₂O

Molecular Weight: 172.19

Cell-Permeable?: Yes

Purity: ≥97%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An activator of mutant p53

MDL Number: MFCD04037877

PubChem CID: 3801471

SMILES: C=CC1=NC(=O)C2=CC=CC=C2N1

InChi: InChI=1S/C10H8N2O/c1-2-9-11-8-6-4-3-5-7(8)10(13)12-9/h2-6H,1H2,(H,11,12,13)

InChi Key: VCHFWHQHIKFOIC-UHFFFAOYSA-N