SU 1498 | 1836

A potent and selective inhibitor (IC₅₀ = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC₅₀ >50 µM), EGFR-kinase (IC₅₀ >100 µM)and HER-2 kinase (IC₅₀>100 µM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.

SU 1498 is a potent and selective inhibitor (IC₅₀ = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC₅₀ >50 µM), EGFR-kinase (IC₅₀ >100 µM)and HER-2 kinase (IC₅₀>100 µM).

1836 | SU 1498 DataSheet

Alternate Name/Synonyms: Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide

Appearance: Yellow powder

Formulation: N/A

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₀N₂O₂

Molecular Weight: 390.52

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A VEGFR2 inhibitor

MDL Number: MFCD03453026

PubChem CID: 5941539

SMILES: CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2

InChi: InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+

InChi Key: JANPYFTYAGTSIN-FYJGNVAPSA-N