SU 3327 | B2923

SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of c-Jun in cells with an EC₅₀ of 6.23 μM. It restores insulin sensitivity in a mouse model of type-2 diabetes.

SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of c-Jun in cells with an EC₅₀ of 6.23 μM. It restores insulin sensitivity in a mouse model of type-2 diabetes.

B2923 | SU 3327 DataSheet

Alternate Name/Synonyms: 5-((5-nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine; 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine; JNK Inhibitor XIII; BDBM29315

Appearance: Solid

Formulation:

CAS Number: 40045-50-9

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₅H₃N₅O₂S₃

Molecular Weight: 261.3

Cell-Permeable?: True

Purity: 95%

Solubilities: 4 mg/ml in in Ethanol, 50 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of JNK

MDL Number:

PubChem CID: 11837140

SMILES: C1=C(SC(=N1)SC2=NN=C(S2)N)[N+](=O)[O-]

InChi: InChI=1S/C5H3N5O2S3/c6-3-8-9-5(14-3)15-4-7-1-2(13-4)10(11)12/h1H,(H2,6,8)

InChi Key: NQQBNZBOOHHVQP-UHFFFAOYSA-N