SU-6656 | B2334

SU-6656 is a potent and selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). In NIH 3T3 cells, SU-6656 inhibits PDGF-/Src-driven mitogenesis and PDGF-stimulated c-Myc induction. SU-6656 in combination with radiation decrease clonogenic survival of endothelial cells.

SU-6656 is a potent and selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). In NIH 3T3 cells, SU-6656 inhibits PDGF-/Src-driven mitogenesis and PDGF-stimulated c-Myc induction. SU-6656 in combination with radiation decrease clonogenic survival of endothelial cells.

B2334 | SU-6656 DataSheet

Alternate Name/Synonyms: (Z)-2-hydroxy-N,N-dimethyl-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-3H-indole-5-sulfonamide

Appearance: Orange brown solid

Formulation:

CAS Number: 330161-87-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₂₁N₃O₃S

Molecular Weight: 371.45

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >10 mg/ml (DMSO)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective Src tyrosine kinase inhibitor

MDL Number: MFCD10565928

PubChem CID: 5312137

SMILES: CN(C)S(=O)(=O)C1=CC2=C(C=C1)NC(=O)C2=CC3=CC4=C(N3)CCCC4

InChi: InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-

InChi Key: LOGJQOUIVKBFGH-YBEGLDIGSA-N