SU 6668 | 1931

Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.

SU 6668 is a potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.

1931 | SU 6668 DataSheet

Alternate Name/Synonyms: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

Appearance: Orange red solid

Formulation: N/A

CAS Number: 252916-29-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₈N₂O₃

Molecular Weight: 310.35

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~100 mM)

Handling: Protect from light

Country of Origin: USA

Tag Line: A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases

MDL Number: MFCD00149792

PubChem CID: 5995546

SMILES: CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

InChi: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6- 15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9+

InChi Key: NHFDRBXTEDBWCZ-NTEUORMPSA-N