Description
KEY FEATURES: • Amine reactive Sulfo-NHS ester that crosslinks efficiently with primary amine-containing molecules • Has a maleimide functional group that can be utilized to react specifically with cysteines or sulfhydryl (-SH) groups • Water-soluble; can be used under physiologic conditions • Has a spacer arm length of 8.3 Å (9 atom) • Unlike other maleimide-activated antibodies, those made with Sulfo-SMCC crosslinkers are often more stable, due to the inductive stabilizing effects of the cyclohexyl ring moeity APPLICATIONS: • Routinely used to prepare hapten-carrier protein and antibody-enzyme conjugates, such as HRP conjugation. • Wide range of uses for both small molecule reactions and large biomolecule applications.
Sulfo-SMCC is a water-soluble heterobifunctional protein crosslinker.
Alternate Name/Synonyms: 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 92921-24-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₇N₂NaO₉S
Molecular Weight: 436.37
Cell-Permeable?: No
Purity: ≥90% by NMR
Solubilities: H₂O (>10 mg/ml)
Handling: Protect from moisture
Country of Origin: USA
Tag Line: A water-soluble heterobifunctional protein crosslinker
MDL Number: MFCD00054978
PubChem CID: 4618794
SMILES: C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CC(C3=O)S(=O)(=O)[O-].[Na+]
InChi: InChI=1S/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1
InChi Key: VUFNRPJNRFOTGK-UHFFFAOYSA-M
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |