Syrosingopine | B1323

Syrosingopine is an inhibitor of the vesicular monoamine transporters. Recently, it has been shown that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Syrosingopine sensitizes cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound.

Syrosingopine is an inhibitor of the vesicular monoamine transporters. Recently, it has been shown that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Syrosingopine sensitizes cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound.

B1323 | Syrosingopine DataSheet

Alternate Name/Synonyms: Methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate; Syringopine; Syrosingopin; Singoserp; Ipores

Appearance: Off-white to pale brown solid

Formulation: N/A

CAS Number: 84-36-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₅H₄₂N₂O₁₁

Molecular Weight: 666.72

Cell-Permeable?: No

Purity: ≥90% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of the vesicular monoamine transporters.

MDL Number: MFCD00017411

PubChem CID: 6769

SMILES: CCOC(=O)OC1=C(C=C(C=C1OC)C(=O)OC2CC3CN4CCC5=C(C4CC3C(C2OC)C(=O)OC)NC6=C5C=CC(=C6)OC)OC

InChi: InChI=1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3/t19-,23+,25-,28-,29+,32+/m1/s1

InChi Key: ZCDNRPPFBQDQHR-SSYATKPKSA-N