T-705 (Favipiravir) | 2778

T-705 (Favipiravir) is an antiviral drug that selectively inhibits the RNA-dependent RNA polymerase of influenza virus. It is phosphoribosylated by cellular enzymes to its active form, favipiravir-ribofuranosyl-5'-triphosphate (RTP). Favipiravir is active against a broad range of influenza viruses, including A(H1N1)pdm09, A(H5N1) and the recently emerged A(H7N9) avian virus. It also inhibits influenza strains resistant to current antiviral drugs, and shows a synergistic effect in combination with oseltamivir, thereby expanding influenza treatment options. Recently, T-705 has been shown to give 100% protection against aerosol Ebola virus E718 infection in immune-deficient mice as well as inhibiting Ebola virus infection in cell culture.

T-705 (Favipiravir) is an antiviral drug that selectively inhibits the RNA-dependent RNA polymerase of influenza virus. It is phosphoribosylated by cellular enzymes to its active form, favipiravir-ribofuranosyl-5'-triphosphate (RTP). Favipiravir is active against a broad range of influenza viruses, including A(H1N1)pdm09, A(H5N1) and the recently emerged A(H7N9) avian virus. It also inhibits influenza strains resistant to current antiviral drugs, and shows a synergistic effect in combination with oseltamivir, thereby expanding influenza treatment options. Recently, T-705 has been shown to give 100% protection against aerosol Ebola virus E718 infection in immune-deficient mice as well as inhibiting Ebola virus infection in cell culture.

2778 | T-705 (Favipiravir) DataSheet

Alternate Name/Synonyms: 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide; Avigan

Appearance: Light yellow to yellow solid

Formulation: N/A

CAS Number: 259793-96-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅H₄FN₃O₂

Molecular Weight: 157.1

Cell-Permeable?: Y

Purity: ≥98%

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An antiviral drug

MDL Number: N/A

PubChem CID: 492405

SMILES: C1=C(N=C(C(=O)N1)C(=O)N)F

InChi: InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)

InChi Key: ZCGNOVWYSGBHAU-UHFFFAOYSA-N