TAE-226 | 9436

TAE-226 is a potent ATP-competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE-226 can block FAK and IGF-IR signaling pathways. TAE-226 inhibits the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines.

TAE-226 is a potent ATP-competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE-226 can block FAK and IGF-IR signaling pathways. TAE-226 inhibits the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines.

9436 | TAE-226 DataSheet

Alternate Name/Synonyms: 2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide; NVP-TAE226

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 761437-28-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅ClN₆O₃

Molecular Weight: 468.94

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive inhibitor of FAK and IGF-IR

MDL Number: N/A

PubChem CID: 9934347

SMILES: CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC

InChi: InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)

InChi Key: UYJNQQDJUOUFQJ-UHFFFAOYSA-N