Description
TAK-063 is a highly potent, cell-permeable PDE10A inhibitor (IC₅₀ = 0.30 nM) with excellent selectivity (>15000-fold selective over other PDEs).
TAK-063 is a highly potent, cell-permeable PDE10A inhibitor (IC₅₀ = 0.30 nM) with excellent selectivity (>15000-fold selective over other PDEs).
Alternate Name/Synonyms: 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1238697-26-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₁₇FN₆O₂
Molecular Weight: 428.42
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly potent, cell-permeable PDE10A inhibitor
MDL Number: N/A
PubChem CID: 46848915
SMILES: COC1=CN(N=C(C1=O)C2=CC=NN2C3=CC=CC=C3)C4=C(C=C(C=C4)N5C=CC=N5)F
InChi: InChI=1S/C23H17FN6O2/c1-32-21-15-29(19-9-8-17(14-18(19)24)28-13-5-11-25-28)27-22(23(21)31)20-10-12-26-30(20)16-6-3-2-4-7-16/h2-15H,1H3
InChi Key: KVHRYLNQDWXAGI-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
