Description
TAK-700 is a potent and highly selective human 17,20-lyase inhibitor (IC₅₀ = 38 nM). Displays >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Displays antiandogen activity.
TAK-700 is a potent and highly selective human 17,20-lyase inhibitor (IC₅₀ = 38 nM). Displays >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Displays antiandogen activity.
Alternate Name/Synonyms: 6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide; Orteronel
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 566939-85-3, 426219-18-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₇N₃O₂
Molecular Weight: 307.35
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and highly selective human 17,20-lyase inhibitor
MDL Number: N/A
PubChem CID: 9796590
SMILES: CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O
InChi: InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1
InChi Key: OZPFIJIOIVJZMN-SFHVURJKSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |