TAME Hydrochloride | 2050

A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.

TAME Hydrochloride is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region.

2050 | TAME Hydrochloride DataSheet

Alternate Name/Synonyms: N-p-Tosyl-L-arginine methyl ester hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 1784-03-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₂₂N₄O₄S.HCl

Molecular Weight: 378.87

Cell-Permeable?: No

Purity: ≥98% by TLC

Solubilities: Water (50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An anaphase-promoting complex/cyclosome (APC/C) inhibitor

MDL Number: MFCD00012578

PubChem CID: 3083734

SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC.Cl

InChi: InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20, 21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H

InChi Key: JIQFFACVQXXHMY-UHFFFAOYSA-N