TAPI-0 | 2067

Inhibitor of TNF-α processing (IC₅₀ = 100 nM). Inhibits TACE (ADAM17) and other metalloproteases with Ki (nM) values of 8.8, 17, 6, 68, 0.5 and 0.2 for TACE, MDC9 (ADAM9), MMP-1, MMP-3, MMP-9 and MMP-13, respectively.

TAPI-0 is an inhibitor of TNF-α processing (IC₅₀ = 100 nM). Inhibits TACE (ADAM17) and other metalloproteases with Ki (nM) values of 8.8, 17, 6, 68, 0.5 and 0.2 for TACE, MDC9 (ADAM9), MMP-1, MMP-3, MMP-9 and MMP-13, respectively.

2067 | TAPI-0 DataSheet

Alternate Name/Synonyms: N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide; TNF protease inhibitor-0; C1

Appearance: White solid

Formulation: N/A

CAS Number: 143457-40-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₄H₃₂N₄O₅

Molecular Weight: 456.55

Cell-Permeable?: No

Purity: ≥95% by HPLC

Solubilities: DMSO (~ 5 mg/ml) or acetic acid (~ 5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An inhibitor of TNF-α processing

MDL Number: MFCD02684279

PubChem CID: 3035404

SMILES: CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)N

InChi: InChI=1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1

InChi Key: CRCPLBFLOSEABN-VBSNWNEZSA-N