Description
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery. Inhibits calcium-dependent signal transduction and cytoskeletal reorganization.
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon catheter injury to the rat common carotid artery. Inhibits calcium-dependent signal transduction and cytoskeletal reorganization.
Alternate Name/Synonyms: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Appearance: Yellow solid
Formulation: N/A
CAS Number: 193620-69-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₁₉NO₃
Molecular Weight: 357.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A smooth muscle cell migration and proliferation inhibitor
MDL Number: N/A
PubChem CID: 9885087
SMILES: COC1=CC=C(C=C1)C(=C2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)OC
InChi: InChI=1S/C23H19NO3/c1-26-17-11-7-15(8-12-17)21(16-9-13-18(27-2)14-10-16)22-19-5-3-4-6-20(19)24-23(22)25/h3-14H,1-2H3,(H,24,25)
InChi Key: KUEYYIJXBRWZIB-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |