Description
Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is tho?ght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.
3549R | Tau Antibody DataSheet
Antibody Target: Tau
Target Alternative Name: tau , TAU , MAPT , MAPTL , FTDP-17 , MSTD , mgC138549 , PPND , MTBT2
Tag Line:
Category: Tau
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human, mouse, rat, chicken, bovine
Immunogen Sequence: Synthetic peptide surrounding amino acid 395 of rat Tau
Accession #: EDM06298
Gene ID: 29477
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.5 mg/ml
Formulation: 30 µg (0.5 mg/ml) affinity purified rabbit anti-TAU polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification: Affinity purified
Application: Western blot
Positive Control:
Application And Usages: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody recognizes mainly the truncated Tau (~30 kDa) in sample from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized. Reactivity to other species has not been tested.
Country of Animal Origin: China
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Not Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified:
Flow Cytometry Verified: Not Verified
Additional Information
Size: |
30 ug |
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |