Tau Antibody | 3549R

Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is tho?ght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.

3549R | Tau Antibody DataSheet

Antibody Target: Tau

Target Alternative Name: tau , TAU , MAPT , MAPTL , FTDP-17 , MSTD , mgC138549 , PPND , MTBT2

Tag Line:

Category: Tau

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human, mouse, rat, chicken, bovine

Immunogen Sequence: Synthetic peptide surrounding amino acid 395 of rat Tau

Accession #: EDM06298

Gene ID: 29477

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 30 µg (0.5 mg/ml) affinity purified rabbit anti-TAU polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Purification: Affinity purified

Application: Western blot

Positive Control:

Application And Usages: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined. The antibody recognizes mainly the truncated Tau (~30 kDa) in sample from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized. Reactivity to other species has not been tested.

Country of Animal Origin: China

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified:

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified