Tavaborole | B2296

Tavaborole (AN2690) is a potent, broad-spectrum antifungal agent that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′ adenosine of tRNA(leu) at the editing site of fungal, but not bacterial LeuRS, locking the enzyme in an inactive conformation. Useful for the topical treatment of toenail onychomycosis.

Tavaborole (AN2690) is a potent, broad-spectrum antifungal agent that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′ adenosine of tRNA(leu) at the editing site of fungal, but not bacterial LeuRS, locking the enzyme in an inactive conformation. Useful for the topical treatment of toenail onychomycosis.

B2296 | Tavaborole DataSheet

Alternate Name/Synonyms: 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole; AN-2690; AN2690

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 174671-46-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₇H₆BFO₂

Molecular Weight: 151.93

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A broad-spectrum antifungal agent

MDL Number: N/A

PubChem CID: 11499245

SMILES: B1(C2=C(CO1)C=C(C=C2)F)O

InChi: InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2

InChi Key: LFQDNHWZDQTITF-UHFFFAOYSA-N