Tazarotene | B1812

Tazarotene is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis, acne vulgaris and photoaging. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.

Tazarotene is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis, acne vulgaris and photoaging. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.

B1812 | Tazarotene DataSheet

Alternate Name/Synonyms: 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 118292-40-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₂₁NO₂S

Molecular Weight: 351.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml) or EtOH (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective retinoic acid receptor (RAR) agonist

MDL Number: MFCD00867628

PubChem CID: 5381

SMILES: CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C

InChi: InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3

InChi Key: OGQICQVSFDPSEI-UHFFFAOYSA-N