Tbk1 Antibody| F45532-0.08ML/F45532-0.4ML/R31230

Tbk1 Antibody| F45532-0.08ML/F45532-0.4ML/R31230 | Gentaur UK, US & Europe Distribution

Background: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Mouse

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the Tbk1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Tbk1 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 8-35 from the mouse protein was used as the immunogen for this Tbk1 antibody.

Storage: Aliquot the Tbk1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A