TC-E 5003 | B1177

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.5 μM); displays no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells.

TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.5 μM); displays no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells.

B1177 | TC-E 5003 DataSheet

Alternate Name/Synonyms: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 17328-16-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₆H₁₄Cl₂N₂O₄S

Molecular Weight: 401.26

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective protein arginine methyltransferase 1 (PRMT1) inhibitor

MDL Number: MFCD00028183

PubChem CID: 87052

SMILES: C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl

InChi: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)

InChi Key: SHRCVZJKZJGIHQ-UHFFFAOYSA-N