TCS 21311 | B2927

TCS 21311 is a potent JAK3 (Janus kinase 3) inhibitor. It shows high selectivity for JAK3 over JAK1, JAK2 and TYK2 with IC₅₀ values of 8 nM, 1017 nM, 2550 nM and 8055 nM respectively. It also inhibits GSK-3β, PKCα and PKCθ with IC₅₀ values of 3 nM, 13 nM and 68 nM, respectively.

TCS 21311 is a potent JAK3 (Janus kinase 3) inhibitor. It shows high selectivity for JAK3 over JAK1, JAK2 and TYK2 with IC₅₀ values of 8 nM, 1017 nM, 2550 nM and 8055 nM respectively. It also inhibits GSK-3β, PKCα and PKCθ with IC₅₀ values of 3 nM, 13 nM and 68 nM, respectively.

B2927 | TCS 21311 DataSheet

Alternate Name/Synonyms: 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione; 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; JAK3 Inhibitor XII, NIBR3049

Appearance: Solid

Formulation:

CAS Number: 1260181-14-3

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₂₇H₂₅F₃N₄O₄

Molecular Weight: 526.51

Cell-Permeable?: True

Purity: 95%

Solubilities: ~50 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent JAK3 inhibitor

MDL Number:

PubChem CID: 50925411

SMILES: CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O

InChi: InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)

InChi Key: CLGRAWDGLMENOD-UHFFFAOYSA-N