Description
TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM). Displays high selectivity over Pim-2 and MEK1/2 (IC₅₀ >20 µM).
TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM). Displays high selectivity over Pim-2 and MEK1/2 (IC₅₀ >20 µM).
Alternate Name/Synonyms: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Appearance: Yellow solid
Formulation: N/A
CAS Number: 491871-58-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₁BrN₂O₂
Molecular Weight: 367.2
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>35 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive Pim-1 kinase inhibitor
MDL Number: MFCD00276275
PubChem CID: 1235170
SMILES: C1=CC=C(C=C1)C2=C(C(=O)NC(=C2)C3=C(C=CC(=C3)Br)O)C#N
InChi: InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
InChi Key: SVSYJTYGPLVUOZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |