TDZD-8 | 2854

TDZD-8 is a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC₅₀ = 2 µM), binding to the active site of GSK3β. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC₅₀s = >100 µM). TDZD-8 also causes rapid death of leukemia stem and progenitor cells.

TDZD-8 is a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC₅₀ = 2 µM), binding to the active site of GSK3β. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC₅₀s = >100 µM). TDZD-8 also causes rapid death of leukemia stem and progenitor cells.

2854 | TDZD-8 DataSheet

Alternate Name/Synonyms: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Appearance: White solid

Formulation: N/A

CAS Number: 327036-89-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₀N₂O₂S

Molecular Weight: 222.26

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent GSK3β inhibitor

MDL Number: MFCD04973552

PubChem CID: 4124851

SMILES: CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2

InChi: InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChi Key: JDSJDASOXWCHPN-UHFFFAOYSA-N