Telaprevir | B1235

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease. Telaprevir inhibits the hepatitis C virus NS3-4A serine protease, blocking the viral polyprotein processing. The dose dependent process leads to decrease in viral RNA replication, decreased HCV RNA and protein levels in con1 subgenomic HCV replicon cells.

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease. Telaprevir inhibits the hepatitis C virus NS3-4A serine protease, blocking the viral polyprotein processing. The dose dependent process leads to decrease in viral RNA replication, decreased HCV RNA and protein levels in con1 subgenomic HCV replicon cells.

B1235 | Telaprevir DataSheet

Alternate Name/Synonyms: (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

Appearance: White Solid

Formulation: N/A

CAS Number: 402957-28-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₆H₅₃N₇O₆

Molecular Weight: 679.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A hepatitis C virus protease inhibitor

MDL Number: MFCD11616089

PubChem CID: 3010818

SMILES: CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3CCCC3CN2C(=O)C(C(C)(C)C)NC(=O)C(C4CCCCC4)NC(=O)C5=NC=CN=C5

InChi: InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1

InChi Key: BBAWEDCPNXPBQM-GDEBMMAJSA-N