Temozolomide | 2226

A DNA methylating agent. A second-generation imidazotetrazine prodrug that undergoes spontaneous conversion under physiological conditions to the active alkylating agent MTIC (3-methyl-(triazen-1-yl)imidazole-4-carboxamide). Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors.

A DNA methylating agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors.

2226 | Temozolomide DataSheet

Alternate Name/Synonyms: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; NSC 362856; CCRG 81045

Appearance: Beige solid

Formulation: N/A

CAS Number: 85622-93-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₆N₆O₂

Molecular Weight: 194.15

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A DNA methylating agent.

MDL Number: MFCD00866492

PubChem CID: 5394

SMILES: CN1C(=O)N2C=NC(=C2N=N1)C(=O)N

InChi: InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChi Key: BPEGJWRSRHCHSN-UHFFFAOYSA-N