TEMPOL | B3100

TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It is a membrane permeable, free radical scavenger. It inhibits lipid peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, in rat liver microsomes with 50% inhibition values of 117 μM, 61 μM, and 381 μM respectively. It reduces oxidative stress mediated renal dysfunction and injury in the rat. TEMPOL decreases proinflammatory cytokines (cytokine storm) and decreases platelet aggregation which may be useful in the treatment of COVID-19.

TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It is a membrane permeable, free radical scavenger. It inhibits lipid peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, in rat liver microsomes with 50% inhibition values of 117 μM, 61 μM, and 381 μM respectively. It reduces oxidative stress mediated renal dysfunction and injury in the rat. TEMPOL decreases proinflammatory cytokines (cytokine storm) and decreases platelet aggregation which may be useful in the treatment of COVID-19

B3100 | TEMPOL DataSheet

Alternate Name/Synonyms: 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy; TMPN; HyTEMPO; 4-Hydroxy-TEMPO; 1-λ1-oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol

Appearance: Orange powder

Formulation:

CAS Number: 2226-96-2

Structure Available?: Yes

Peptide sequence:

Salt Form: No

Molecular Formula: C₉H₁₈NO₂

Molecular Weight: 172.24

Cell-Permeable?: True

Purity: ≥ 97%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A membrane permeable, free radical scavenger

MDL Number: MFCD00006478

PubChem CID: 137994

SMILES: CC1(CC(CC(N1[O])(C)C)O)C

InChi: InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3

InChi Key: UZFMOKQJFYMBGY-UHFFFAOYSA-N