TG-101209 | B3220

TG101209 is a potent and selective inhibitor of Janus Kinase 2 (JAK2) (IC50 = 6 nM). It displays 28-fold selectivity over JAK3 (IC50 = 169 nM). TG101209 induces dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines.

TG101209 is a potent and selective inhibitor of Janus Kinase 2 (JAK2) (IC50 = 6 nM). It displays 28-fold selectivity over JAK3 (IC50 = 169 nM). TG101209 induces dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines.

B3220 | TG-101209 DataSheet

Alternate Name/Synonyms: N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide

Appearance: White to off-white solid

Formulation:

CAS Number: 936091-14-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₅N₇O₂S

Molecular Weight: 509.67

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent JAK2 inhibitor

MDL Number:

PubChem CID: 16722832

SMILES: CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C

InChi: InChI=1S/C26H35N7O2S/c1-19-18-27-25(29-20-9-11-22(12-10-20)33-15-13-32(5)14-16-33)30-24(19)28-21-7-6-8-23(17-21)36(34,35)31-26(2,3)4/h6-12,17-18,31H,13-16H2,1-5H3,(H2,27,28,29,30)

InChi Key: JVDOKQYTTYUYDV-UHFFFAOYSA-N