TG003 | 1905

Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (Ki = 10 nM for mClk1/Sty; IC₅₀ = 20 nM, 200 nM, >10 µM, and 15 nM for mClk1, mClk2, mClk3, and mClk4, respectively). Recently, it has been shown that TG003 promotes the skipping of exon 31 in the endogenous dystrophin gene in a dose-dependent manner and increases the production of the dystrophin protein.

TG003 is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (Ki = 10 nM for mClk1/Sty; IC₅₀ = 20 nM, 200 nM, >10 µM, and 15 nM for mClk1, mClk2, mClk3, and mClk4, respectively).

1905 | TG003 DataSheet

Alternate Name/Synonyms: (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 300801-52-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₅NO₂S

Molecular Weight: 249.33

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk)

MDL Number: MFCD00624584

PubChem CID: 647991

SMILES: CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C

InChi: InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3

InChi Key: BGVLELSCIHASRV-UHFFFAOYSA-N