TGN-020 | B2979

TGN-020 is an inhibitor of aquaporin 4 (AQP4), the most abundant water channel in brain. It inhibits AQP4 inhibitor with an IC₅₀ of 3 μM in vitro. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduces ischemic cerebral edema associated with focal cerebral ischemia in a mouse model.

TGN-020 is an inhibitor of aquaporin 4 (AQP4), the most abundant water channel in brain. It inhibits AQP4 inhibitor with an IC₅₀ of 3 μM in vitro. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduces ischemic cerebral edema associated with focal cerebral ischemia in a mouse model.

B2979 | TGN-020 DataSheet

Alternate Name/Synonyms: N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide; n-(1,3,4-thiadiazol-2-yl)nicotinamide; 2-(Nicotinamido)-1,3,4-thiadiazole

Appearance: Solid

Formulation:

CAS Number: 51987-99-6

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₈H₆N₄OS

Molecular Weight: 206.22

Cell-Permeable?: True

Purity: 98%

Solubilities: ~4 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An aquaporin 4 inhibitor

MDL Number:

PubChem CID: 4173511

SMILES: C1=CC(=CN=C1)C(=O)NC2=NN=CS2

InChi: InChI=1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)

InChi Key: AGEGZHOPKZFKBP-UHFFFAOYSA-N