Theliatinib | B3004

Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05 nM and IC₅₀ of 3 nM. It exhibits strong antitumor activity in patient-derived estrogen cancer xenograft (PDECX) models with high EGFR expression, including remarkable tumor regression in two PDECX models with both EGFR gene amplification and protein overexpression in a dose-dependent manner (5 and 15 mg/kg/day). The efficacy of theliatinib is reduced in the models with PI3KCA mutations or FGFR1 overexpression in addition to high EGFR expression.

Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05 nM and IC₅₀ of 3 nM. It exhibits strong antitumor activity in patient-derived estrogen cancer xenograft (PDECX) models with high EGFR expression, including remarkable tumor regression in two PDECX models with both EGFR gene amplification and protein overexpression in a dose-dependent manner (5 and 15 mg/kg/day). The efficacy of theliatinib is reduced in the models with PI3KCA mutations or FGFR1 overexpression in addition to high EGFR expression.

B3004 | Theliatinib DataSheet

Alternate Name/Synonyms: HMPL-309; (3aR,6aR)-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxamide

Appearance: Solid

Formulation:

CAS Number: 1353644-70-8

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₅H₂₆N₆O₂

Molecular Weight: 442.5

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~5 mg/ml in DMSO. May need ultrasonication.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective EGFR inhibitor

MDL Number:

PubChem CID: 54759275

SMILES: CN1CCC2C1CN(C2)C(=O)NC3=C(C=C4C(=C3)C(=NC=N4)NC5=CC=CC(=C5)C#C)OC

InChi: InChI=1S/C25H26N6O2/c1-4-16-6-5-7-18(10-16)28-24-19-11-21(23(33-3)12-20(19)26-15-27-24)29-25(32)31-13-17-8-9-30(2)22(17)14-31/h1,5-7,10-12,15,17,22H,8-9,13-14H2,2-3H3,(H,29,32)(H,26,27,28)/t17-,22+/m1/s1

InChi Key: FSXCKIBROURMFT-VGSWGCGISA-N