Thiazovivin | 1681

Cell-permeable. Helps in promoting human embryonic stem cell (hESC) survival by > 30-fold. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 (Cat. No. 1674) and PD 0325901 (Cat. No.1643).Acts as a Rho-associated Kinase (ROCK) inhibitor. Tzv (2 µM) inhibits ROCK activity and protect hESCs at a similar level as Y-27632 (10 µM) (Cat. No. 1596), a well-known, selective ROCK inhibitor.

Thiazovivin helps in promoting human embryonic stem cell (hESC) survival by > 30-fold. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 (Cat. No. 1674) and PD 0325901 (Cat. No.1643). Acts as a Rho-associated Kinase (ROCK) inhibitor. Tzv (2 µM) inhibits ROCK activity and protect hESCs at a similar level as Y-27632 (10 µM) (Cat. No. 1596), a well-known, selective ROCK inhibitor.

1681 | Thiazovivin DataSheet

Alternate Name/Synonyms: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide; Tzv

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1226056-71-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₃N₅OS

Molecular Weight: 311.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A hESC survival agent

MDL Number: MFCD16495823

PubChem CID: 46209426

SMILES: C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3

InChi: InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13- 6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)

InChi Key: DOBKQCZBPPCLEG-UHFFFAOYSA-N