Thiostrepton | 9677

Thiostrepton is a large cyclic antibiotic commonly used in topical antibiotic ointments. It inhibits bacterial protein synthesis. It blocks translation by interfering with elongation factors (EF) involved in ribosomal GTPase activity. Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Thiostrepton is a large cyclic antibiotic commonly used in topical antibiotic ointments. It inhibits bacterial protein synthesis. It blocks translation by interfering with elongation factors (EF) involved in ribosomal GTPase activity. Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

9677 | Thiostrepton DataSheet

Alternate Name/Synonyms: Alaninamide, Bryamycin, Thiactin

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1393-48-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₇₂H₈₅N₁₉O₁₈S₅

Molecular Weight: 1664.89

Cell-Permeable?: Yes

Purity: Assay: ≥900 u/mg

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antibiotic and protein synthesis inhibitor

MDL Number: MFCD00135828

PubChem CID: 16129666

SMILES: CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C

InChi: InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,

InChi Key: NSFFHOGKXHRQEW-DVRIZHICSA-N