Description
Thymoquinone is a natural phytochemical that displays anti-inflammatory properties, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC₅₀= 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.
Thymoquinone is a natural phytochemical that displays anti-inflammatory properties, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC₅₀= 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.
B2172 | Thymoquinone DataSheet
Alternate Name/Synonyms: 2-Isopropyl-5-methyl-1,4-benzoquinone; NSC 2228
Appearance: Off-white/yellow/orange solid
Formulation: N/A
CAS Number: 490-91-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₀H₁₂O₂
Molecular Weight: 164.2
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~14 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A biologically active natural product
MDL Number: MFCD00001602
PubChem CID: 10281
SMILES: CC1=CC(=O)C(=CC1=O)C(C)C
InChi: InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3
InChi Key: KEQHJBNSCLWCAE-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |