Thymoquinone | B2172

Thymoquinone is a natural phytochemical that displays anti-inflammatory properties, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC₅₀= 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.

Thymoquinone is a natural phytochemical that displays anti-inflammatory properties, blocking the synthesis of leukotrienes. It inhibits the growth of leukemia cells (IC₅₀= 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.

B2172 | Thymoquinone DataSheet

Alternate Name/Synonyms: 2-Isopropyl-5-methyl-1,4-benzoquinone; NSC 2228

Appearance: Off-white/yellow/orange solid

Formulation: N/A

CAS Number: 490-91-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₂O₂

Molecular Weight: 164.2

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~14 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A biologically active natural product

MDL Number: MFCD00001602

PubChem CID: 10281

SMILES: CC1=CC(=O)C(=CC1=O)C(C)C

InChi: InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3

InChi Key: KEQHJBNSCLWCAE-UHFFFAOYSA-N