Tirabrutinib hydrochloride | B2556

Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton’s Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton’s Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

B2556 | Tirabrutinib hydrochloride DataSheet

Alternate Name/Synonyms: GS4059, ONO-WG-307, GS 4059, GS-4059, ONO-4059, ONO4059 HCl, (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 1439901-97-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₃ClN₆O₃

Molecular Weight: 490.95

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent Bruton's Tyrosine Kinase (BTK) inhibitor

MDL Number:

PubChem CID: 71571562

SMILES: CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl

InChi: InChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1

InChi Key: UQYDCIJFACDXSG-GMUIIQOCSA-N