TLR2 Antibody (Clone BV31-9) | 3569

The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Up-to-date, ten TLRs (TLR1-10) have been described. TLR2 is differentially expressed in human cells. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells. CD3+ T-cells and CD56+ NK cells did not express TLR2. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulate TLR2, whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

3569 | TLR2 Antibody (Clone BV31-9) DataSheet

Antibody Target: TLR2

Target Alternative Name: Toll-like receptor 2 , TLR2 , Anti-TLR2 , CD282 , TIL4

Tag Line:

Category: TLR

Host: Mouse

Isotype: Mouse IgG1

Species Reactivities: Human

Immunogen Sequence: Recombinant human TLR2

Accession #: O60603

Gene ID: 7097

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 100 µl protein G purified mouse anti-human TLR2 monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.

Purification:

Application: Western blot

Positive Control:

Application And Usages: Western blotting (1:200-1000 dilution). However, the optimal conditions should be determined individually. Ramos cell lysate can be used as a positive control and a ~86 kDa band is detected.

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified:

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified