TLR2-IN-C29 | B2121

TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. It prevents the early activation of TLR2-mediated signaling, including NF-κB and MAPKs, as well as MyD88 recruitment to TLR2 in THP-1 cells.

TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. It prevents the early activation of TLR2-mediated signaling, including NF-κB and MAPKs, as well as MyD88 recruitment to TLR2 in THP-1 cells.

B2121 | TLR2-IN-C29 DataSheet

Alternate Name/Synonyms: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid; TLR2 inhibitor C29

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 363600-92-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₅NO₄

Molecular Weight: 285.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A TLR2/1 and TLR2/6 signaling inhibitor

MDL Number: N/A

PubChem CID: 5945409

SMILES: CC1=C(C=CC=C1NC=C2C=CC=C(C2=O)OC)C(=O)O

InChi: InChI=1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,17H,1-2H3,(H,19,20)/b11-9-

InChi Key: MTKNDEJJSOGOPA-LUAWRHEFSA-N